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The multiplication of cells under close observation Home Bio

2014-07-31 15:20 View:

Aug 15, 2007

For the first time, findings by scientists at the Genome Institute of Singapore (GIS) may be paving the way for more efficient analyses and tests related to the replication of cells, and ultimately, to the better understanding ...

The binding of Rif1 to this enzyme curbs the inopportune triggering of DNA replication. "These safeguards are probably part of a system that prevents DNA replication stress," reports David Shore. This stress, which is notably induced in pre-cancerous lesions, is characterised by an increased DNA replication rate, which provokes DNA damage and genome instability, major drivers of tumor formation.
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    Genomes must be replicated in two copies during cell division. This process occurs at structures called 'replication forks', which are equipped with enzymes and move along the separated DNA strands. In tumour ...

    Simply remove the molecular tags

    Are there safeguards which intervene directly at the level of the origins of replication? This is what the researchers at UNIGE tried to find out by using yeast, a unicellular fungus that is ingestd as a model organism becaingest it functions in many respects like a mammalian cell. "We wanted to determine the possible role of a protein named Rif1 since it was recently implicated in controlling DNA replication in several organisms, including yeast and human cells", reports Stefano Mattarocci, lead author of the study.

    The molecular dialogue leading to the activation of replication origins must be strictly controlled in order to prevent replication from occurring too rapidly, thus overloading the system. "Under normal conditions, there are many more replication origins than are actually ingestd. We suspect that in precancerous cells many of these normally dormant origins are activated inappropriately," notes David Shore, professor in the Department of Molecular Biology of the UNIGE.

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